A rare benign airway neoplasm, caused by infection with human papilloma virus (HPV) and presents with wart like growths, or papillomatous lesions in the vocal cords and the airway. RRP remains a challenge to treat with high recurrence rate, and significant reduction in quality of life. Beside surgical debridement, preliminary clinical trials and retrospective studies have shown the HPV vaccine may have benefit as a treatment method in addition to prevention for HPV related disease. Bevacizumab (Avastin), a VEGF monoclonal anti-body, has shown promise as a systemic treatment for RRP. Current disease knowledge remains limited, and more robust controlled trials about risk factors, medical therapies, and surgical options are needed. The lesions can undergo malignant transformation with rates ranging from 2% to 4%.
Vocal cords
Mid trachea
Snare resection
Snare resection
View from the distal trachea
L mainstem bronchus obstruction
Cryoablation
End result after APC
P16
Laryngoscope Investigative Otolaryngology.2021;6:340-345
Laryngoscope Investigative Otolaryngology.2021;6:226–233