86-year-old-female, ex smoker who presents with chest discomfort and dyspnea
Bronchoscopy with mediastinal staging, radial EBUS/fluoro and tumor sampling came back positive for moderately differentiated squamous cell carcinoma, T2bN0M0, stage IIA
H&E-stained sections demonstrate multiple fragments of airway with one fragment showing infiltrative nests of pleomorphic squamoid cells with few mitotic figures identified and background fibrous stroma. Immunohistochemistry performed for p40, TTF-1, and
synaptophysin show the cells to be positive for p40 and negative for the other markers.